Chemotherapy was potentiated by E7449 and single agent had sizeable antitumor action in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell strains, probable as a result of TNKS inhibition. In step with this likelihood, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization https://vistusertib88765.blogolenta.com/26226404/the-ultimate-guide-to-lycorine